Choosing The Right IVF Treatment Type: Fresh Or Frozen


The calculations of frozen embryo transfers, which permit for pre-implantation genetic testing (PGT), have greatly exceeded fresh embryo transfers as observed recently but different aspects generally trigger the judgment on these events. The technology has come a long way, and in many IVF centers, frozen embryo transfers (FETs) are more prevalent than fresh IVF cycles. 

For a fresh IVF transfer to be successful it’s an obligation that you should have a good embryo, a good uterine lining, and good hormone levels whereas in a Frozen Embryo Transfer ( FET) cycle, we can optimally develop the uterine lining and hormone levels, and in many circumstances, this improves the chances for pregnancy. 

Some IVF cycles have pre implantation genetic testing (PGT) of embryos which need to have a frozen embryo transfer to get the expected test results back and those embryos must be genetically normal to transfer.

What Is Pre-Implantation Genetic Testing? 

Pre implantation genetic testing is carried out in mothers who carry an X-linked genetic disorder called adrenoleukodystrophy and have a 50% chance of passing on the disorder to their son. This test was triumphantly carried out for the first time in 1990. The embryos were screened in the presence of a Y chromosome, and only female embryos were implanted. The technology has been continually developed and refined since then. Today, this testing can detect a wide range of genetic conditions.

Is It Still Reasonable To Do Fresh IVF Embryo Transfers?

There are many studies which reveal that if a woman is under the age of 35, and does not have a too drastic response to IVF medication, has a good uterine lining, and has progesterone hormones in the ideal range, have shown live birth rates with fresh embryo transfers when compared with  Frozen Embryo transfers (FETs). Live birth rates are a key metric in understanding the IVF success rates, and are almost equal to FETs if the embryo for the FET was genetically tested (PGT).

It has been observed that in women between 35-37 years of age, live birth rates with fresh embryo transfers are higher than FETs if those frozen embryos were not genetically tested (PGT), but lower than FETs with PGT embryos.

Now when it came to women who are 38 years of age and older, fresh embryo transfers had a lower live birth rate than FETs with and without PGT. The most distinguished success rates in this age group were seen in the patients doing FET cycles with PGT.

The Benefits Of Pre Implantation Genetic Testing (PGT) With IVF

PGT is more valuable as a woman grows older since a greater percentage of eggs left in her ovaries are genetically unusual as she ages. Older studies have recommended that PGT may be indicated in women 38 and older who do IVF. Still, as PGT technology and IVF laboratories have become more reliable, it has been noticed that even younger women may benefit from PGT in an IVF cycle.

Conclusion 

Comparing live birth rate by age in Frozen Embryo Transfer cycles with and without PGT, it has been observed that 9 percent higher live birth rate in women under 35 with PGT whereas there is a 20 percent increase in live birth rate in the women age group of 35-37, and 38-41. Therefore, which treatment will give you the best chance at success depends on your age and your clinical situation.

At the Institute of Reproductive Medicine & IVF Centre, we believe every woman earns the opportunity to become a biological mother. With one of the best facilities of Infertility treatment in Delhi and expertise of Dr. RK Sharma, you have the right to accurate and honest information about the treatment options which are open to you.



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